Mandel was born in Detroit, Michigan but grew up in Morton Grove, Illinois, a suburb of Chicago. His first record was the album Stand Back! Here Comes Charley Musselwhite's Southside Band in 1966 with Charlie Musselwhite. Described in 1997's Legends of Rock Guitar as a "legendary" album, it was influential in bridging the gap between blues and rock and roll, with Mandel's "relentless fuzztone, feedback-edged solos, and unusual syncopated phrasing.
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